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Hormones influence everything from energy levels to immune function. For people living with autoimmune conditions, hormonal shifts can have a noticeable effect on symptoms. This is especially true for women, whose bodies go through regular and sometimes dramatic hormonal changes throughout life. Understanding these shifts can help you better anticipate flares and adjust your care plan when needed.

Hormonal shifts that may affect symptoms

• Menstrual cycles
• Pregnancy and postpartum changes
• Perimenopause and menopause
• Birth control or hormone therapy use
• Thyroid hormone imbalances

How hormones influence the immune system

Hormones like estrogen, progesterone, and cortisol help regulate immune responses. When these levels rise or fall—naturally or due to medication—they can alter how the immune system behaves. For some, this may trigger inflammation or worsen symptoms. Others may notice improvement at certain points in their cycle.

The relationship between hormones and autoimmune disease is complex, but many patients and providers observe symptom patterns linked to hormonal fluctuations.

Common symptom changes during hormonal shifts

• Increased joint pain or swelling
• Fatigue or brain fog before or during menstruation
• Mood changes or irritability tied to hormone levels
• Flares during perimenopause or after childbirth
• Worsening symptoms when stopping or starting hormone therapy

Tracking your cycle and symptoms

Keeping a symptom journal can help you identify whether hormonal changes are playing a role in how you feel. Tracking your cycle along with fatigue, pain, or mood can reveal helpful patterns. This information can be used to adjust medications, lifestyle habits, or flare management strategies.

Working with your care team

• Talk to your rheumatologist about any cycle-related flares
• Ask whether hormone therapy may help or hinder your symptoms
• Coordinate care with a gynecologist or endocrinologist if needed
• Explore non-hormonal ways to ease symptoms, like diet, sleep, and movement

Your symptoms are valid

If your autoimmune symptoms seem to come and go with hormonal changes, you’re not imagining it. Hormones can play a significant role in how your condition behaves, and recognizing that connection gives you more control. By staying informed and supported, you can work with your body instead of against it.

Your Symptoms Matter

If you’re ready to take the next step toward clarity and relief, the team at TIR Specialists in Amarillo is here to walk with you, providing compassionate care, expert guidance, and personalized treatment plans designed to help you regain control, reduce discomfort, and improve your quality of life.